(015) STOMP: Sexual function Trial of Overactive bladder: Medication versus PTNS

Abstract Introduction Female sexual dysfunction affects approximately 45% of women, and an even greater percentage those with overactive bladder (OAB). Sexual function, measured by the Function Index (FSFI), has been shown to improve treatment OAB. To date, no study compared effects percutaneous tibial nerve stimulation (PTNS) versus medication (anticholinergics (ACH) or beta-agonists (BAG)) on function. Objectives The objective this was compare effect PTNS medical therapy (MT) ACH BAG female Methods This a prospective multi-center cohort study. Sample sizes 63 per group were calculated be necessary detect clinically relevant difference in primary end point, FSFI. Sexually-active women OAB completed Overactive Bladder questionnaire (OAB-q), FSFI, Beck Depression Inventory visual analog pain scale prior after 12 weeks therapy. Results 175 patients recruited 104 follow up (58/108 ACH, 31/49 BAG, 13/18 PTNS). had lower overall FSFI (p=0.04), worse (p=0.01) decreased lubrication (p=0.006) groups. After there significant differences between groups sub-domain scores. There within-group from pre- post-treatment, worsening arousal (p=0.046) improvement (p=0.04) BAG. treatment, postmenopausal significantly better (p=0.01), desire (p=0.003), (p=0.009) orgasm (p=0.01). Conclusions While both MT improved OAB, resulted aspects such as arousal, while function pain. Improvement pronounced sub-group women. further research necessary, provides additional information about comparative treatments which may ultimately lead patient selection outcomes. Disclosure No.